Bcr abl from molecular mechanisms of leukemia induction to treatment of chronic myelogenous leukemia this review will first describe the molecular pathophysiology of cml then discuss novel . Advances in treatment of chronic myeloid leukemia cml have been made over the past two decades thanks to research that has furthered our understanding of its molecular pathogenesis cml is a clonal hematopoietic stem cell disorder charac terized by the abnormal proliferation of myeloid cell lineages which progresses. Treatment of chronic myelogenous leukemia cml with interferon alpha frequently results in normalization of peripheral blood counts and in up to 20 of patients reestablishment of normal . Advances in treatment of chronic myeloid leukemia cml have been made over the past two decades thanks to research that has furthered our understanding of its molecular pathogenesis. Chronic myeloid leukemia cml also known as chronic myelogenous leukemia is a cancer of the white blood cells it is a form of leukemia characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood
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